Nutritional, Metabolic, Endocrine Paediatrics Malnutrition
Conditions
Interventions
F75 and F100 Nutritional Milk feeds
B. Standard treatment WHO feeds (F75/F100) plus a non-digestible fermentable carbohydrate as inulin
Cereal-based recipe for WHO feeds (F75/F100) plus a non-digestible fermentable carbohydrate as cowpe
Sponsors
Imperial College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Anthropometric features of severe acute malnutrition as per WHO Child Growth Standards (2006): 1. Marasmus: Mid-upper arm circumference (MUAC) <11.5cm or Weight-for-height Z-score (WHZ) < -3 2. Kwashiorkor: Symmetrical pitting oedema involving at least the feet irrespective of WHZ score or MUAC 3. Guardian or parent willing and able to provide consent
Exclusion criteria
Exclusion criteria: Children with severe acute malnutrition with a very high risk of early death will be excluded: ¿ Impaired consciousness: one of prostration (inability to sit unsupported or inability to breast feed if 3s, lower limb temperature gradient or weak radial pulse volume. ¿ Severe dehydration: Sunken eyes and reduced skin turgor in the presence of diarrhoea (3 or more episodes of profuse and watery stool) ¿ Respiratory distress: increased work of breathing and hypoxia (oxygen saturation < 90% in air) Additionally children who cannot complete accurate dietary recall will be excluded: ¿ Exclusively breast-fed infants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Co-primary outcome measures: 1.Weight gain (moderate to good: >5g/kg/day) 2.Survival to Day 28 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical outcome : a.Time to diarrhoea resolution (if >3 loose stools/day) b. Time to oedema resolution c. Time to return of appetite d. Time to nutritional rehabilitation | — |
Countries
Uganda
Contacts
Public ContactJSO Obbo
The Chairman MRRH-REC
Outcome results
None listed