Bicarbonate in Obstructed Labour

Conditions

Pregnancy and Childbirth Obstructed Labour

Mukunya D, Musaba MW, Nambozo B, Oguttu F, Makoko BT, Napyo A, Nantale R, Wani S, Tumuhamye J, Auma P, Atim K, Wamulugwa J, Nahurira D, Okello D, Ssegawa L, Wandabwa J, Kiguli S, Chebet M.

2024-02-011 citations

10.1186/s40885-023-00261-6

Effect of pre-operative bicarbonate infusion on maternal and perinatal outcomes among women with obstructed labour in Mbale hospital: A double blind randomized controlled trial

Milton W. Musaba, Julius Wandabwa, Grace Ndeezi, Andrew Weeks, David Mukunya et al. (11 authors)

PLoS ONE2021-02-0910 citations

10.1371/journal.pone.0245989

Effect of preoperative bicarbonate infusion on maternal and perinatal outcomes of obstructed labour in Mbale Regional Referral Hospital: a study protocol for a randomised controlled trial

Milton W. Musaba, Justus K. Barageine, Grace Ndeezi, Julius Wandabwa, Andrew Weeks

BMJ Open2019-04-0112 citations

10.1136/bmjopen-2018-026675

Interventions

Pre-operative Sodium Bicarbonate infusion

Only standard preoperative care

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1.Have a singleton pregnancy 2.Gestation age of at least 37 weeks 3. Cephalic presentation 4. A live baby.

Exclusion criteria

Exclusion criteria: 1. Those with other obstetric conditions like APH, PE/E, PROM and IUFD 2. Those with other commodities like DM, SCD & heart disease 3. Those who are unable to give informed consent 4. Are not willing to be followed up to the end of the study 5. Those with hypernatraemia at baseline (> 148mEq/L) 6. Those with alkalosis at baseline (> 22mEq/L)

Design outcomes

Primary

Measure	Time frame
Maternal, mean lactate in capillary blood at one hour after onset of study drug administration;Newborn, arterial cord blood lactate at birth (Foetal acidosis)	—

Secondary

Measure	Time frame
venous cord blood lactate;Apgar score;Admission to NICU;Perinatal death;Neonatal sepsis;Myometrial Lactate;Primary postpartum haemorrhage;Birth canal trauma;Duration of hospital stay;Puerperal sepsis;Fistulae;Duration of hospital stay;Puerperal sepsis;Obstetric fistulae	—

Countries

Uganda

Contacts

Public ContactMilton Musaba

Obstetrician&Gynaecologist

miltonmusaba@gmail.com+256704913791

Outcome results

None listed