Comparing the effects of mass drug administration using Praziquantel drug with and without diagnosis on treatment compliance

Integrating use of point-of-care Circulating Cathodic Antigen rapid diagnostic tests by Community Health Workers during Mass Drug Administration campaigns to improve uptake of praziquantel treatment among the adult population at Kome Island, North-Western Tanzania: A cluster randomized Community Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201804003343404

Enrollment

5000

Registered

2018-04-22

Start date

2017-08-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System intestinal schistosomiasis

Interventions

diangosis using Point-of-care circulating cathodic antigen test

Receive only praziquantel without diagnosis

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (i) aged 18 years and above (ii) willing to participate and give written informed consent (iii) Living in the study area

Exclusion criteria

Exclusion criteria: i) Pregnant at the time of treatment (ii) history of adverse reaction to praziquantel (iii) Present with serious conditions at the time of treatment and not deemed fit to take treatment

Design outcomes

Primary

Measure	Time frame
the proportion of study participants provided with praziquantel drug (treatment coverage) and geographical cluster (a service area of the community health workers) in the intervention and control arms	—

Secondary

Measure	Time frame
Community Health Workers (CHWs) ability to use POC-CCA rapid test accurately and safely;Community members acceptability (these are people¿s perceptions and attitude on the two-treatment approach) of POC-CCA test results offered by community health workers;Experience of Community Health Workers on the use of POC-CCA rapid diagnostic test	—

Countries

United Republic of Tanzania

Contacts

Public ContactDomenica Morona

Director of Research and Innovation

dmorona@gmail.com+2552500881

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026