Malaria Paediatrics
Conditions
Interventions
Aggressive Antipyretics
Sponsors
University of Rochester
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Evidence of P. falciparum malaria infection by peripheral blood smear or rapid diagnostic test. 2. CNS symptoms associated with malaria. Cerebral malaria: Impaired consciousness with a Blantyre Coma Score (BCS)(73)less than or equal to 2 in children under 5 yrs or a Glasgow Coma Score (GCS)less than or equal to 10 in children greater than or equal to 5 yrs OR CNS MALARIA: Complicated seizure(s), meaning prolonged (>15 minutes), focal or multiple; or impaired consciousness or other evidence of impaired consciousness (confusion, delirium) without frank coma (BCS>2,GCS=11-14).
Exclusion criteria
Exclusion criteria: 1. Circulatory failure (cold extremities, capillary refill > 3 seconds, sunken eyes, decreased skin turgor). 2. Vomiting in the past 2 hrs. 3. Serum Cr> 1.2 mg/dL. 4. A hx of liver disease. 5. Jaundice or a total bilirubin of >3.0mg/dL. 6. A hx of gastric ulcers or gastrointestinal bleeding. 7. A hx of thrombocytopenia or other primary hematologic disorder. 8. Petechiae or other clinical indications of bleeding abnormalities. 9. A known allergy to ibuprofen, acetaminophen, aspirin or any non-steroidal medication. 10. Any contraindication for nasogastric tube (NGT) placement and/or delivery of enteral medications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean maximum temperature (TMAX). Continuous temp monitors not MRI compatible. If TMAX is clinical temp obtained when continuous monitoring data not available, clinical TMAX will be used as primary outcome | — |
Secondary
| Measure | Time frame |
|---|---|
| Seizures;Parasite burden | — |
Countries
Malawi, Zambia
Contacts
Public ContactMoses Chilombe
Researcher
Outcome results
None listed