Digestive System Liver Enzymes
Conditions
Interventions
Group A
Group B
Sponsors
Cairo University
Kasr Alainy Hospitals
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Adult healthy ASA I, II patients, both genders, aged 18 ¿ 60 years, with stationary elevated liver enzymes < 2 folds undergoing elective lower abdominal wall or limb surgeries with expected operation time less than 2 hours
Exclusion criteria
Exclusion criteria: ¿ ASA class III or IV ¿ Age >60 years or <18 years ¿ Patients undergoing intraperitoneal and laparoscopic procedures. ¿ Acute viral hepatitis: inflammation of the liver caused by infection with one of the five hepatitis viruses. In most people, the inflammation begins suddenly and lasts only a few weeks. ¿ Acute alcoholic hepatitis: is inflammation of the liver due to excessive intake of alcohol. It is usually found in association with fatty liver, an early stage of alcoholic liver disease, and may contribute to the progression of fibrosis, leading to cirrhosis. ¿ Severe chronic hepatitis: is inflammation of the liver that lasts at least 6 months. ¿ Child¿s C class classification: this score is used to assess the prognosis of chronic liver disease, mainly cirrhosis. ¿ Severe coagulopathy: a pathological condition that reduces the ability of the blood to coagulate, resulting in uncontrolled bleeding. A platelet count of < 50 x 109 /L will be considered at high risk of increased bleeding. ¿ Severe extrahepatic complication (Hypoxemia, Acute renal failure¿) ¿ Pregnant, diabetic patients ¿ Patients having an auto-immune disease ¿ Patients taking anticoagulant drugs or drugs that cause elevated liver enzymes (non-steroidal anti-inflammatory drugs, antibiotics, antiepileptic drugs, inhibitors of hydroxyl-methyl-glutaryl¿coenzyme a reductase (statins), and anti-tuberculosis drugs) were excluded from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the pre and postoperative liver enzymes | — |
Countries
Egypt
Outcome results
None listed