Safety and efficacy of dexmedetomidine, ketofol and propofol for sedation of mechanically ventilated patients

Safety and efficacy of dexmedetomidine, ketofol and propofol for sedation of mechanically ventilated patients in intensive care unit

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201803003203136

Enrollment

Registered

2018-03-15

Start date

2015-11-21

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory mechanically ventilated patients in the intensive care unit.

Interventions

Group1: 30 patients will receive ketofol an initial bolus dose (500mcg/kg) of ketamine/propofol1:1 (

Group2: 30 patients will receive loading dose infusion of dexmedetomidin (precedex ) diluted in 0.

Group3: 30 patients will receive Propofol (diprivan) undiluted as an infusion of 1-3mg/kg/h, after a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ¿ Adult patients(18yr or older) ¿ The patients whose will require a minimum of 24h artificial ventilation after complex major surgery ¿ The patients need for sedation

Exclusion criteria

Exclusion criteria: ¿ Patients with increased intracranial tension ¿ Patients with known allergies to the studied Drugs

Design outcomes

Primary

Measure	Time frame
Ramsay Sedation Scale	—

Countries

Egypt

Contacts

Public Contactdoaa rashwan

Assistant professor Faculty of medicine, Beni Sueif University

doaa_rashwan@hotmail.com01011270763

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026