CXL PLUS for Treatment of Keratoconus

Conventional 30 Minutes Epithelium-off Cross-Linking Versus CXL PLUS (Combined Photorefractive Keratectomy with Accelerated Epithelium-off Cross-Linking) for Keratoconus Management: A Comparative Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201801002951377

Enrollment

Registered

2018-01-07

Start date

2015-02-02

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Eye Diseases Keratoconus

Interventions

conventional 30 minutes epithelium -off CXL

CXL PLUS ( combined CXL and PRK )

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All patients were diagnosed with grade 1 (early KC) according to Amsler-Krumeich classification. All corneal topographic and refractive parameters of the eye followed specific criteria. The central corneal thickness at the thinnest location was less than 400 µm, the spherical equivalent including both myopic and astigmatic KC components was less than 5 D while the mean k readings less than 48 D.

Exclusion criteria

Exclusion criteria: Any KC which is not classified as grade 1 KC.

Design outcomes

Primary

Measure	Time frame
The conventional 30 minutes epithelium-off CXL had similar results to CXL PLUS	—

Secondary

Measure	Time frame
conventional 30 minutes epithelium-off CXL is much powerful than accelerated CXL	—

Countries

Egypt

Contacts

Public ContactAhmed Saber

ahmed.saber.pro@gmail.com+201119499395

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026