Mechanism underlying insulin resistance in black South African women: Lessons from an intervention study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201711002789113

Enrollment

Registered

2017-11-21

Start date

2015-06-21

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine Insulin resistance, obesity

Interventions

Exercise Group

Control Group

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: * black South African women (based on the Xhosa ancestry of both parents) between the ages of 20-35 years; * obese (BMI 30-40 kg/m2); * weight stable (weight not changed more than 5 kg or no change in clothes size over the past 6 months); * sedentary (not participating in exercise training (>1 session of >20 min per week) within the last 12 months); * on injectable contraceptive (depot medroxyprogesterone acetate, 400 mg) for a minimum of 2 months; * no known metabolic or inflammatory diseases; * not taking any medications; * not currently pregnant or lactating; * no orthopedic or medical problems that may prevent exercise participation; *no surgical procedures within the last 6 months.

Exclusion criteria

Exclusion criteria: * hypertension (¿140/90 mmHg); * diabetes (random plasma glucose concentration of >11.1 mmol/l and/or HbA1c result >6.5%); * human immunodeficiency virus (HIV); * anemia (hemoglobin (Hb) <12 g/dl);

Design outcomes

Primary

Measure	Time frame
Insulin Sensitivity and Secretion	—

Countries

South Africa

Contacts

Public ContactJulia Goedecke

Senior Scientist/South African Medical Research Council

julia.goedecke@uct.ac.za+27828255616

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026