Polycystic Ovary Syndrome PCOS
Conditions
Interventions
Sponsors
Emaduldin Seyam
Minia University Obstetrics and Gynecology department
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: A randomized, double-blind controlled study was performed using combined Simvastatin and metformin with PCOS unmarried women in a tertiary care centre in Upper Egypt. The diagnosis of PCOS was based on the availability of the three diagnostic criteria of the Rotterdam consensus, namely clinical and biochemical evidence of hyperandrogenaemia (Ferriman-Gallwey score (FGS), free androgen index (FAI) respectively), oligomenorrhea or amenorrhea and polycystic ovaries on transabdominal ultrasound
Exclusion criteria
Exclusion criteria: Women recruited had no concurrent illness, and were not on any prescription or over-the-counter medication which might affect insulin sensitivity, lipids or ovarian function including hormonal contraceptives for the preceding six months. 21-hydroxylase deficiency, hyperprolactinaemia, Cushing¿s disease and androgen-secreting tumors were excluded by appropriate tests. All women were young unmarried and not planning to marry at least till the end of study period. Recruited women were advised not to change their lifestyle, including physical activity or dietary habits, during the study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Spontaneous ovulation improvement | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of the clinical, and biochemical abnormalities assocaited with PCOS | — |
Countries
Egypt
Contacts
Public ContactMarwa Mohamed
Specialist in Obstetrics and Gynecology
Outcome results
None listed