Nervous System Diseases Surgery spine surgery
Conditions
Interventions
Sponsors
faculty of medicine, Mansoura universisty
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: - aged 18¿55 years, - American Society of Anesthesiologists (ASA) score I-II - admitted to undergo elective lumbar discectomy or spinal fixation surgery under general anesthesia
Exclusion criteria
Exclusion criteria: - Patients on anti-hypertensive treatment, diuretics, corticosteroids, pregabalin, gabapentin, anticonvulsants, antipsychotics, alcohol addiction, drug abuse or any analgesics within 48 hours before surgery. - patients with history of allergy to any drug used in the study. - pregnant or nursing women. - patients with peripheral neuropathy, endocrinal diseases, bleeding abnormality, cardiac, hepatic or renal impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative consumption of nitroglycerin to maintain the target MAP 55- 65 mmHg. | — |
Secondary
| Measure | Time frame |
|---|---|
| estimated blood loss ;The number of transfused blood unites;heart rate (HR) and invasive MAP;end-tidal isoflurane concentration;Surgeon satisfaction about the field (scale 0-5);Sedation (by Ramsay sedation scale);The time to the first request of analgesia.;Postoperative pain (by VAS 0-10 scale);The total morphine consumption;Frequency of adverse effects as dizziness, headache, nausea and vomiting, or pruritus.;Peak and plateau airway pressures | — |
Countries
Egypt
Contacts
Public ContactAlaa Mazy
associate profesor of anesthesia and surgical intensive care
Outcome results
None listed