Adjuncts to general anesthetics in spine surgery

Perioperative effects of preoperative oral pregabalin or clonidine in patients undergoing lumbar spine posterior fusion

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201710002416280

Enrollment

Registered

2017-07-11

Start date

2017-08-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases Surgery adjucts to general anesthetics in spine surgery Anaesthesia

Interventions

Group P

Group C

group A

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ¿Adult patients, 18 to 65 years old. ¿American society of anesthesiologists class I or II. ¿Body mass index 25- 40 kg/m2. ¿Normo-tensive patients, systolic blood pressure not more than 140 mmHg and diastolic not more than 90 mmHg.

Exclusion criteria

Exclusion criteria: ¿Body mass index more than 40 kg/m2. ¿Previous spine surgery or pain intervention. ¿Poorly controlled arterial hypertension (blood pressure higher than 140/90 mmHg). ¿Respiratory, liver, psychiatric or kidney disease. ¿Heart disease (heart block, or myocardial ischemia). ¿Diabetes mellitus (altered pain perception) ¿Pregnant females. ¿Patients on ¿2 agonist or ¿ blocker therapy. ¿History of hypersensitivity to any of the study drugs.

Design outcomes

Primary

Measure	Time frame
anesthetic consumption;intraoperative blood loss: blood volume in the suction container and the number of the bloody gauze pads. ;hemodynamics : HR, MAP, Need for nitroglycerin, ephedrine or atropine for maintaining the hemodynamics within the predetermined hemodynamics range. Incidence of intraoperative complications as hypotension/ hypertension, tachycardia/ bradycardia. ;postoperative VAS, analgesic consumption, Time for first postoperative analgesia requirement	—

Measure

Time frame

anesthetic consumption;intraoperative blood loss: blood volume in the suction container and the number of the bloody gauze pads. ;hemodynamics : HR, MAP, Need for nitroglycerin, ephedrine or atropine for maintaining the hemodynamics within the predetermined hemodynamics range. Incidence of intraoperative complications as hypotension/ hypertension, tachycardia/ bradycardia. ;postoperative VAS, analgesic consumption, Time for first postoperative analgesia requirement

—

Secondary

Measure	Time frame
Extubation time;postoperative side effects: Incidence and severity of side-effects such as PONV, shivering, sedation, headache, visual disturbance and respiratory depression ;sedation level by Ramsay Sedation Scale;PACU discharge time (min).	—

Countries

Egypt

Contacts

Public Contactwesamuddin sultan

lecturer in aneaesthesia and intesnive care

wesamsultan@gmail.com00201010122125

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026