A RCT comparing eMPC to paper-based model with regards to glucose control in trauma ICU patients

Insulin therapy and glucose control in ICU: a prospective, randomised, controlled trial comparing enhanced model predictive control to paper-based method in critically ill trauma patients

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201710000932829

Enrollment

Registered

2014-11-07

Start date

2015-01-05

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nutritional, Metabolic, Endocrine Glucose control in critically ill trauma patients

Interventions

enhanced model predictive control

paper-based insulin infusion protocol

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1)critically ill trauma patients requiring ICU admission 2) no threshold serum glucose necessary for inclusion; insulin infusion to be commenced on admission 3) non-diabetics only 4) anticipated length of stay of at least 24 hours 5) intravenous insulin administration via peripheral or central line 6) arterial line for blood sampling

Exclusion criteria

Exclusion criteria: 1) patient or family refusal 2) pregnancy 3) burns 4) traumatic brain injury with GCS <8 5) moribund with likely demise within 24 hours 6) Diabetics, DKA or hyperosmolar state 7) renal dysfunction

Design outcomes

Primary

Measure	Time frame
average serum glucose variability	—

Secondary

Measure	Time frame
average time spent within target serum glucose range;overall mean serum glucose levels;time spent above target range;serum glucose sampling interval	—

Countries

South Africa

Contacts

Public ContactLowellen Clarke

Registrar, Anaesthesia

lowellenclarke@gmail.com021 404 5000

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026