Therapeutic efficacy testing of drug

Conditions

Malaria

Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke Idowu Ayede et al. (36 authors)

Infectious Diseases of Poverty2019-08-0619 citations

Clinical illness and outcomes in Nigerian children with persistent early-appearing anaemia following initiation of artemisinin-based combination treatments of uncomplicated falciparum malaria

Kazeem Akano, Bayo Fatunmbi, Godwin Ntadom, Adejumoke Idowu Ayede, Temitope Aderoyeje et al. (22 authors)

Parasite2019-01-01

10.1051/parasite/2019058

Parasite reduction ratio one day after initiation of artemisinin-based combination therapies and its relationship with parasite clearance time in acutely malarious children.

Akano K, Ntadom G, Agomo C, Happi CT, Folarin OA, Gbotosho GO, Mokuolu O, Finomo F, Ebenebe JC, Jiya N, Ambe J, Wammanda R, Emechebe G, Basorun OK, Wewe OA, Amoo S, Ezeigwe N, Oguche S, Fatunmbi B, Sowunmi A.

2018-12-074 citations

10.1186/s40249-018-0503-7

Factors contributing to anaemia after uncomplicated falciparum malaria in under five year-old Nigerian children ten years following adoption of artemisinin-based combination therapies as first-line antimalarials.

Sowunmi A, Fatunmbi B, Akano K, Wewe OA, Agomo C, Finomo F, Ebenebe J, Jiya N, Ambe J, Wammanda R, Ntadom G, Mokuolu O, Emechebe G, Ezeigwe N, Ayede AI, Adewoye EO, Gbotosho GO, Folarin OA, Happi CT, Oguche S, Oyibo WA, Useh F.

2017-12-196 citations

10.1186/s12879-017-2876-9

Interventions

Artemether-lumefantrine

Artesunate-amodiaquine

Dihydroartemisinin-piperaquine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients were included in the study if they satisfied the following criteria: Age 6 - 59 months, History of fever / presence of fever (temp >/= 37.5oC), Mono Plasmodium falciparum infection with parasitemia of 2,000 - 200,000 asexual forms per mL and Written informed consent, including readiness to comply with follow up visits by the child's parent or guardian.

Exclusion criteria

Exclusion criteria: Patients were excluded from the study if they had any of the following: Signs of severe malaria or other danger signs, such as: 1. Hyperparasitaemia >200,000 2. Altered consciousness 3. Inability to sit or stand unsupported 4. Severe anaemia (Hb </= 5 g/dL) 5. Convulsions 6. Shock (systolic BP < 50 mmHg, and or presence of cold clammy extremities, fast thready pulses) 7. Inability to drink or breastfeed 8. Vomiting everything, Severe malnutrition, History of allergy to test drugs

Design outcomes

Primary

Measure	Time frame
Early treatment failure;Late clinical failure`;Late parasitological failure;Adequate clinical and parasitological response	—

Secondary

Measure	Time frame
Parasites and fever clearance times;Gametocyte carriage	—

Countries

Nigeria

Contacts

Public ContactGodwin Ntadom

Asst. Coordinator

ntadomg@yahoo.com07085100800

Outcome results

None listed