Comparative Study between Hydrocortisone and Caffeine in Treatment of Postdural Puncture Headache: A Randomized Double-Blind Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201708002484171

Enrollment

Registered

2017-07-30

Start date

2016-11-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Postdural puncture headache Anaesthesia

Interventions

Hydrocortisone and Caffeine

PDPH

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: patients aged 18¿50 years of both sexes, ASA physical status I¿II of 70¿90 kg body weight and height 160¿180 cm.

Exclusion criteria

Exclusion criteria: Patients with impaired kidney or liver functions, history of cardiac or central nervous system disease (a history of convulsions, cerebro-vascular accident, pre-eclampsia, eclampsia or high intracranial pressure), history of drug or alcohol abuse, history of chronic pain or daily intake of analgesics, uncontrolled medical disease (diabetes mellitus and hypertension), history of intake of non-steroidal anti-inflammatory drugs or opioids within 24 h before surgery or allergy to the used medications, coagulation defect, patient refusal or duration of surgery more than 120 min were excluded from the study.

Design outcomes

Primary

Measure	Time frame
primary measure was to compare between hydrocortisone and caffeine in treatment of PDPH within 48 h.	—

Secondary

Measure	Time frame
secondary measure of the study was to find out a non-invasive effective rapid treatment of PDPH.	—

Countries

Egypt

Contacts

Public ContactTamer Safan

Lecurer of Anesthesia

safan.tamer@hotmail.com0020123337850

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026