Efficacy of simvastatin in treating patients with traumatic brain injury.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201708002405365

Enrollment

Registered

2017-07-06

Start date

2015-05-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Nervous System Diseases traumatic brain injury

Interventions

Placebo

simvastatin

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: acute Traumatic brain injury age range from 18 to 60 years admitted to Intensive care unit within 24 hours

Exclusion criteria

Exclusion criteria: history of allergy to statins myopathies patients with major organ dysfunction (renal, liver, cardiovascular) drug or alcohol abuse pregnancy or lactation life threatening multiple trauma administration of fibrates, niacin, or corticosteroid drugs psychiatric disorder past history of neurological illness, prolonged Q-T interval expected to die imminently (< 24 hours) signs of brain stem failure.

Design outcomes

Primary

Measure	Time frame
Glasgow Coma Scale level and plasma level of Amyloid precursor protein .	—

Secondary

Measure	Time frame
APACHE II score, Intensive care unit mortality and Glasgow outcome scale	—

Countries

Egypt

Contacts

Public ContactAbeer Hassanin

Assisstant professor of anesthesia and ICU

abeerhassanine@yahoo.com00201004234010

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026