Comparing the proportion of hypoxia in sedated adults undergoing OGD using TCI propofol versus intermittent boluses

A randomized controlled trial comparing the proportion of hypoxia in sedated adults undergoing upper gastrointestinal endoscopy using target controlled infusion of propofol versus intermittent boluses.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201708002325400

Enrollment

176

Registered

2017-05-26

Start date

2016-12-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory hypoxia

Interventions

Target controlled infusion of Propofol

Intermittent bolus administration of Propofol

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All ASA I and II adults aged 18 - 65 years scheduled to undergo non-emergent upper gastrointestinal endoscopy under sedation.

Exclusion criteria

Exclusion criteria: ¿Known allergy to propofol, midazolam, soybean, egg. ¿Active respiratory tract infection. ¿History or indicator of large airway compromise e.g. obstructive sleep apnoea, COPD, presence of stridor, or known history of difficult bag-valve-mask ventilation. ¿Patients requiring additional types of sedative agents to achieve optimal sedation. ¿History of chronic exposure to sedative medication.

Design outcomes

Primary

Measure	Time frame
To compare the proportion of hypoxia between the two study groups	—

Secondary

Measure	Time frame
To compare the proportion of hypotension and bradycardia between the two study groups	—

Countries

Kenya

Contacts

Public ContactCiru Kamanda

Research Support Unit Administrator

research.supportea@aku.edu+254203662148

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026