PRISM Trial

Prevention of Respiratory Insufficiency after Surgical Management (PRISM) Trial

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201707002360211

Enrollment

4800

Registered

2017-06-15

Start date

2017-06-05

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System Nutritional, Metabolic, Endocrine Intra-peritoneal conditions

Interventions

Continous positive airway pressure (CPAP)

Standard care

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients aged 50 years or over undergoing elective major intra-peritoneal surgery using an open surgical technique.

Exclusion criteria

Exclusion criteria: 1) Inability or refusal to provide informed consent 2) Anticipated requirement for invasive or non-invasive mechanical ventilation for at least four hours after surgery as part of routine care 3) Pregnancy or obstetric surgery 4) Previous enrollment in PRISM trial 5) Current participation in a clinical trial of a treatment with a similar biological mechanism or related primary outcome measure 6) Clinician refusal

Design outcomes

Primary

Measure	Time frame
Composite endpoint of pneumonia, endotracheal re-intubation or death within 30 days of randomisation	—

Secondary

Measure	Time frame
To determine whether routine postoperative CPAP reduces other forms of postoperative morbidity, mortality, or improves quality of life.	—

Countries

South Africa

Contacts

Public ContactMargot;Rowan Flint;Duys

Chief Scientific Officer;Consultant

margot.flint@uct.ac.za;rowanduys@gmail.com0721222111;0214045001

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026