Pregnancy and Childbirth Intrauterine growth restriction
Conditions
Interventions
Sildenafil citrate
Sponsors
Ain Shams university
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Pregnant Women diagnosed as IUGR. 2.Patients aged between 20¿40 years old. 3.Consenting to participate.
Exclusion criteria
Exclusion criteria: 1.Severe preeclampsia with a diastolic blood pressure ¿ 110 mmHg on two occasions or systolic blood pressure ¿ 160 mmHg on two occasions and that, together with significant proteinuria (at least 1g/litre). 2.Fetus with reversed UA end diastolic flow. 3.Fetus diagnosed to have any congenital anomalies. 4.Diabetes mellitus with pregnancy. 5.Any contraindication for conservative management of IUGR as non-reassuring non-stress test (NST). 6.Patients with contraindication for the drugs given as gastric or duodenal ulcer, bleeding tendency and severe hypotension. 7.Smokers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gain in fetal AC. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of days between intervention and termination for fetal indication.;Doppler changes in UA, UV and MCA and whether venous circulation or arterial circulation blood flow will be reversed first.;Maternal blood pressure changes. | — |
Countries
Egypt
Outcome results
None listed