The effect of preoperative sildenafil on operative and early postoperative outcome after mitral valve replacement in patients with pulmonary hypertens

The effect of preoperative adminstration of sildenafil on operative and early postoperative outcome after mitral valve replacement in patients with severe pulmonary hypertension

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201703002106114

Enrollment

Registered

2017-03-15

Start date

2017-04-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System pulmonary hypertension, cardiac surgery

Interventions

group A

group B

group C

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who will be scheduled for elective mitral valve replacement surgery with pulmonary hypertension (pulmonary artery systolic pressure(PASP) ¿50mmHg)

Exclusion criteria

Exclusion criteria: Co-existing coronary artery diseases. Emergency mitral valve replacement. Redo mitral valve replacement. Congestive heart failure. Renal dysfunction, creatinine > 2 mg / dl. Hepatic dysfunction, bilirubin > 3 mg /dl. Chronic obstructive pulmonary disease, FEV1/FEVC< 7. Concomitant aortic valve replacement. Severe tricuspid regurgitation.

Design outcomes

Primary

Measure	Time frame
effect of oral Sildenafil on lowering pulmonary hypertension preoperative	—

Countries

Egypt

Contacts

Public ContactRasha Elsebaey Soliman

assisstant lecturer of cardiothoracic surgery, Faculty of Medicine, Menoufia University

rashacts@gmail.com0201015405423

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026