A comparison of reactive case detection and focal mass drug administration strategies in the Central Highlands areas of Madagascar

A comparison of reactive case detection and focal mass drug administration strategies to inform the national malaria control strategy toward elimination. Cluster Randomized Trial in 14 districts in the Central Highlands areas of Madagascar

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201703002069220

Enrollment

195000

Registered

2017-03-02

Start date

2017-03-27

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria

Interventions

Reactive Case detection

Focal Mass Drug Administration

Control

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ¿ Arm 1(Reactive case detection): all household members and immediate 10-15 neighboring households of a passively detected index case, whether symptomatic or not, with positive RDT results. ¿ Arm 2 (focal Mass drug administration) : all household members and immediate 10-15 neighboring households of a passively detected index case, whether symptomatic or not and regardless of RDT result. ¿ Arm 3 (Control): Passively detected malaria cases.

Exclusion criteria

Exclusion criteria: Patients living in a cluster with a planned focal IRS campaign in the following 2 years

Design outcomes

Primary

Measure	Time frame
Malaria Annual Parasite Incidence (API) in Reactive Case Detection (RCD) and focal Mass drug administration fMDA arms compared to a control arm.	—

Secondary

Measure	Time frame
PCR prevalence of malaria	—

Countries

Madagascar

Contacts

Public ContactJudicaelle Irinantenaina

Clinical Research Coordinator/ Institut Pasteur Madagascar

judi@pasteur.mg+261 20 22 412 72

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026