Effect of isoflurane on diastolic dysfunction

ECHOCARDIOGRAPHIC EVALUATION OF THE EFFECTS OF INCREASE DEPTH OF ANESTHESIA BY ISOFLURANE ON LEFT VENTRICULAR RELAXATION INDICES IN PATIENTS WITH DIASTOLIC DYSFUNCTION IN OPEN HEART SURGERIES

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201701001983201

Enrollment

Registered

2017-01-18

Start date

2017-03-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery Ischemic heart disease with diastolic dysfunction.

Interventions

Dose of isoflurane that cause bispectral index (BSI) reading = 60

Dose of isoflurane that cause bispectral index (BSI) reading = 40

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Non-emergent coronary artery bypass grafting surgery. Left ventricular ejection fraction of 45% or more. Grade 1 diastolic dysfunction.

Exclusion criteria

Exclusion criteria: Cardiac valvular pathology. Myocardial infarction within 4 weeks. Body mass index greater than 40 kg/m2. Pacemaker therapy. Left bundle branch block or Atrial fibrillation. Esophagitis or esophageal varices. Hypertrophic obstructive cardiomyopathy or infiltrative myocardial disease. Emergency CABG and patients coming on inotropes or mechanical ventilation.

Design outcomes

Primary

Measure	Time frame
Trans mitral flow velocity profile measured by by pulsed wave Doppler (PWD).	—

Secondary

Measure	Time frame
Pulmonary vein flow velocity profile measured by PWD.;Tissue Doppler imaging of the mitral annulus.;Hear rate;Mean arterial pressure;central venous pressure	—

Countries

Egypt

Contacts

Public ContactAtef Elsebaie

Specialist anesthetist at national heart institute, Giza, Egypt.

atefelsebaie@yahoo.com00201112182274

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026