Letrozole in first trimester miscarriage

Misoprostol versus letrozole with misoprostol in the management of first trimester missed miscarriage

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201701001973403

Enrollment

552

Registered

2017-01-15

Start date

2015-07-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth First trimester miscarriage

Interventions

Placebo

Letrozole group

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: - First trimester missed miscarriage. - closed cervix. - no products of conception passed

Exclusion criteria

Exclusion criteria: - previous attempts of pregnancy termination. - abnormal uterine lesions as fibroid or congenital malformations. - pregnancy on top of intra-uterine contraceptive device. - medical disorders as heart and haemorrhagic disease. - known hypersensitivity to any of the used medications

Design outcomes

Primary

Measure	Time frame
rate of achieving complete miscarriage and induction to abortion interval	—

Secondary

Measure	Time frame
to measure the time of start of vaginal bleeding, and the development of side effects	—

Countries

Egypt

Contacts

Public ContactHaitham Torky

Department of obstetrics & gynecology October 6th University

haithamtorky@yahoo.com+201001230161

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026