Effect of magnesium sulphate on intraocular pressure

The Effect Of Magnesium Sulphate In Attenuating The Upsurge Of Intraocular Pressure During Rapid Sequence Induction By Suxamethonium Chloride: A Prospective Double-Blinded Randomized Placebo Controlled Trial.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201701001958143

Enrollment

100

Registered

2017-01-02

Start date

2017-02-01

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intraocular pressure rise after suxamethonium administration in rapid sequence induction

Interventions

Magnesium sulphate administration

Saline

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: age 18 - 95 years. ASA 1 and 2. Non-ophthalmic surgery. Rapid sequence induction anaesthesia.

Exclusion criteria

Exclusion criteria: Patients with known hypersensitivity to magnesium sulphate or suxamethonium. Hypocalcemia. Any degree of heart block. Uncontrolled hypertension. Patients with unstable hemodynamics or in need to inotropes or vasopressor support. Morbidly obese (BMI ¿ 40). Any cardiovascular, renal, hepatic or muscular disease. Patients with raised IOP. Patients receiving any drug known to alter IOP. Previous eye surgery. Expected difficult intubation. Require two or more attempts at laryngoscopy for endotracheal tube placement.

Design outcomes

Primary

Measure	Time frame
Intraocular pressure (IOP)	—

Secondary

Measure	Time frame
Mean arterial blood pressure (MAP);Heart rate (HR);Laryngoscopy time ;serum magnesium level;body mass index (BMI);Weight	—

Countries

Egypt

Contacts

Public ContactYasser Salim

Assisstant lecturer of anesthesia and ICU, faculty of medicine, Fayoum University

yasser.salem@yahoo.com0020 1009 3141 78

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026