Malaria
Conditions
Interventions
Intermittent preventive treatment with Dihydroartemisinin/piperaquine
Intermittent prevetive treatment with Sulfadoxine/Pyrimethamine
Daily co-trimoxazole alone given to HIV infected pregnant women
IPTDihydroartemisinin and piperaquine added to daily cotrimoxazole among HIV infected pregnant women
Sponsors
MUHAS
Sida-MUHAS
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: i. Viable pregnancy assessed by UPT ii. Gestational age 16 to 32 weeks (inclusive) determined by fundal height iii. No prior history of IPTp use for current pregnancy iv. Willing to participate and complete the study schedule v. Willing to sign or thumb print informed consent vi. Resident of study area and intending to stay in the area for the duration of the follow-up vii. Willing to deliver at the health facility
Exclusion criteria
Exclusion criteria: i. Residence outside study area or planning to move out in the 12 months following enrolment ii. High risk pregnancy, including any pre-existing illness likely to cause complication of pregnancy (hypertension, diabetes, asthma, epilepsy, renal disease, liver disease, fistula repair, leg or spine deformity) iii. Severe anemia requiring blood transfusion (Hb ¿ 7.0 g/dL) at enrolment iv. Known allergy or previous adverse reaction to any of the study drugs v. Unable to give informed consent (for example due to mental disability) vi. Previous inclusion in the same study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Active or recent placental malaria | — |
Secondary
| Measure | Time frame |
|---|---|
| ¿ Incidence of malaria infection and clinical malaria during pregnancy, defined as fever or recent history of fever in the presence of malaria parasites; ¿ Prevalence of adverse newborn morbidity at birth, defined as a composite of either preterm delivery (<37 weeks¿ gestation), low birth weight (<2500 g), and, anemia (hemoglobin<11 g/dL) during pregnancy or at delivery | — |
Countries
Tanzania
Contacts
Public ContactMwelecele Malcela
Chairperson Medical Research Committee/National Institute for Medical Researches
Outcome results
None listed