Induction of ovulation

Clomiphene citrate combined with metformin versus letrozole for induction of ovulation in clomiphene- resistant polycystic ovary syndrome: a randomized clinical trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201610001802302

Enrollment

200

Registered

2016-10-03

Start date

2016-10-16

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility-female polycystic ovary syndrome

Interventions

Clomiphene citrate 100 mg daily for 5 days combined with metformin 500 mg three times daily

letrozole 2.5 mg twice daily for 5 days.

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: A normal semen analysis, normal uterine cavity and bilateral tubal patency were other criteria of inclusion.

Exclusion criteria

Exclusion criteria: Patients with FSH >15 mIU/ml, endocrine disorders: hyperprolactinaemia (prolactin ¿ 22 ng/dl), thyroid disorders, cushing's syndrome and acromegaly and patients having organic pelvic disease (endometriosis, leiomyoma, PID, endometrioma or ovarian cyst) upon initial examination as well as husband semen abnormalities (severe oligospermia) were excluded from the study.

Design outcomes

Primary

Measure	Time frame
Degree of glycemic control Maternal outcome Fetal-neonatal outcome.;ovulation rate, clinical pregnancy rate.	—

Secondary

Measure	Time frame
patient acceptability and adverse effects of therapy	—

Countries

Egypt

Contacts

Public ContactMohamed Rezk

Lecturer of Obstetrics and Gynecology-Faculty of Medicine-Menoufia University

m_rezk9207@yahoo.com00201006237186

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026