EFFECT OF LOW-DOSE KETAMINE VERSUS FENTANYL ON ATTENUATING THE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOI

A RANDOMIZED CONTROL TRIAL COMPARING THE EFFECT OF LOW-DOSE KETAMINE VERSUS FENTANYL ON ATTENUATING THE HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN PATIENTS UNDERGOING GENERAL ANAESTHESIA AT THE AGA KHAN UNIVERSITY HOSPITAL, NAIROBI

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201610001637385

Enrollment

Registered

2016-05-18

Start date

2015-10-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION Anaesthesia

Interventions

Ketamine

Fentanyl

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: ¿ ASA I and II patients 18-65 years scheduled for non-emergent surgery.

Exclusion criteria

Exclusion criteria: ¿ History of allergy or contraindications to any of the study drugs ¿ Patients scheduled for emergency surgery ¿ Hypertension ¿ i.e. a known/previously diagnosed hypertensive as per the American Heart Association guidelines ¿ Pregnancy ¿ Known ischaemic heart disease ¿ Known raised intracranial pressure or intracranial pathology where a rise in intracranial pressure would pose a risk or patients scheduled for neurosurgical procedures ¿ History, indicator (Mallampati score) of or proven difficult ventilation/laryngoscopy/intubation ¿ Intubation time greater than 30 seconds

Design outcomes

Primary

Measure	Time frame
occurrence of increase in systolic blood pressure (20% increase from baseline)	—

Secondary

Measure	Time frame
occurrence of decrease in systolic blood pressure (20% decrease from baseline)	—

Countries

Kenya

Contacts

Public ContactVitalis Mung'ayi

Faculty Department of Anaesthesiology

vitalis.mung'ayi@aku.edu+254-724-904010

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026