Malnutrition and Antiretroviral Timing in Children with HIV (MATCH)

A comparison of early vs. delayed initiation of HAART in severely malnourished HIV-infected children.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201609001751384

Enrollment

Registered

2016-08-23

Start date

2012-07-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Interventions

Early Arm

Delayed Arm

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age: 1 months - 12 years 2. HIV infection as defined as a positive ELISA or Rapid HIV test in children over 18 months or a positive DNA PCR in children under 18 months. 3. ART-naïve except for antiretroviral prophylaxis given for PMTCT. 4. Severe acute malnutrition (SAM) as defined by WHO criteria: Weight-for-length 3 z-scores below the WHO growth standards median or Mid-upper arm circumference (MUAC) < 115 mm with/without peripheral edema. 5. Eligible for initiation of HAART by the SA national treatment guidelines

Exclusion criteria

Exclusion criteria: 1. Enrollment in other interventional studies. 2. Lack of availability of parent/guardian willing and able to provide informed consent and adhere to study protocol.

Design outcomes

Primary

Measure	Time frame
anthropometric response (BMIZ/WAZ/HAZ);Virological Response (VL<1000c/ml);immunological response	—

Secondary

Measure	Time frame
mortality;adverse events/IRIS events	—

Countries

South Africa

Contacts

Public ContactMoherndran Archary

Hon. Lecturer

archary@ukzn.ac.za+27312604318

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026