Social, Emotional and Economic empowerment thru Knowledge of Group Support Psychotherapy content (SEEK-GSP) Trial

Conditions

Mental and Behavioural Disorders Depression

Shakira Babirye, Rongjie Huang, Chengbo Zeng, Jeremiah Mutinye Kwesiga, Barbara Kemigisha et al. (10 authors)

Wellcome Open Research2026-08-28

10.12688/wellcomeopenres.25768.2

Development and External Validation of a Treatment-Adjusted Machine Learning Model for Precision Allocation of Group-Based Depression Care Among People Living with HIV in Uganda

S. Babirye, Rongjie Huang, Chengbo Zeng, Jeremiah Kwesiga Mutinye, Barbara Kemigisha et al. (10 authors)

Wellcome Open Research2026-04-06

10.12688/wellcomeopenres.25768.1

Long-Term Effect of Group Support Psychotherapy on Depression and HIV Treatment Outcomes: Secondary Analysis of a Cluster Randomized Trial in Uganda

Etheldreda Nakimuli‐Mpungu, Colin M. Smith, Kizito Wamala, James Okello, Josephine Birungi et al. (11 authors)

Psychosomatic Medicine2022-09-0619 citations

10.1097/psy.0000000000001128

Effectiveness and cost-effectiveness of group support psychotherapy delivered by trained lay health workers for depression treatment among people with HIV in Uganda: a cluster-randomised trial.

Nakimuli-Mpungu E, Musisi S, Wamala K, Okello J, Ndyanabangi S, Birungi J, Nanfuka M, Etukoit M, Mayora C, Ssengooba F, Mojtabai R, Nachega JB, Harari O, Mills EJ.

2020-02-0571 citations

10.1016/s2214-109x(19)30548-0

Recruitment and Baseline Characteristics of Participants in the Social, Emotional, and Economic Empowerment Through Knowledge of Group Support Psychotherapy Study (SEEK-GSP): Cluster Randomized Controlled Trial

Etheldreda Nakimuli‐Mpungu, Seggane Musisi, Kizito Wamala, James Okello, Sheila Ndyanabangi et al. (12 authors)

JMIR Research Protocols2018-11-017 citations

10.2196/11560

The Effect of Group Support Psychotherapy Delivered by Trained Lay Health Workers for Depression Treatment Among People with HIV in Uganda: Protocol of a Pragmatic, Cluster Randomized Trial

Etheldreda Nakimuli‐Mpungu, Seggane Musisi, Kizito Wamala, James Okello, Sheila Ndyanabangi et al. (9 authors)

JMIR Research Protocols2017-12-1118 citations

10.2196/resprot.8925

Interventions

Group support psychotherapy

Group HIV education

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: HIV positive Aged 19 years or older Met Mini International Neuropsychiatric Interview (MINI) criteria for major depression Live or work in the villages served by participating lay health worker Be antidepressant naive.

Exclusion criteria

Exclusion criteria: Individuals with the following conditions will be excluded from the study: High suicide risk A severe medical disorder such as pneumonia or active tuberculosis Psychotic symptoms Hearing or visual impairment

Design outcomes

Primary

Measure	Time frame
Major depressive disorder (MDD);Functioning	—

Secondary

Measure	Time frame
Emotional outcomes: Depression,PTSD symptoms,self-esteem;Social outcomes:Alcohol Use & Perceived social support,Coping skills, HIV related stigma, enacted stigma(discrimination) ;Economic outcomes: Poverty index scores & Disability days ;HIV treatment outcomes:Adherence to anti-retroviral therapy(ART) and Viral load;Cost-effectiveness;Process evaluation outcomes: Feasibility& Fidelity ;Process evaluation outcomes: Acceptability, Contextual influences & Causal mechanisms	—

Measure

Time frame

Emotional outcomes: Depression,PTSD symptoms,self-esteem;Social outcomes:Alcohol Use & Perceived social support,Coping skills, HIV related stigma, enacted stigma(discrimination) ;Economic outcomes: Poverty index scores & Disability days ;HIV treatment outcomes:Adherence to anti-retroviral therapy(ART) and Viral load;Cost-effectiveness;Process evaluation outcomes: Feasibility& Fidelity ;Process evaluation outcomes: Acceptability, Contextual influences & Causal mechanisms

—

Countries

Uganda

Contacts

Public ContactHellen Opolot

Adminstrative Assistant to Executive Secretary of the UNCST

info@uncst.go.ug+256414705500

Outcome results

None listed