Safety and Efficacy of Ketamine-Dexmedetomidine versus Ketamind-Propofol Combinations for Sedation in Patients after Coronary Artery Bypass Graft Surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201608001710307

Enrollment

Registered

2016-07-10

Start date

2013-01-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Coronary Artery Bypass Graft surgery

Interventions

ketamine dexmedetomidine

ketamine propfol

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients 40-60 years old hemodynamically stable with normal or moderately impaired left ventricular function ejection fraction (EF) > 40%; who underwent elective coronary artery bypass graft surgery under high-dose opioid anesthesia on mechanical ventilation

Exclusion criteria

Exclusion criteria: - Patient refusal. - Pregnant patients. - Patients with neurologic disease - Patients with liver or renal insufficiency - Hemodynamic instability both intraoperative, post bypass or postoperative - Patients on high dose vasopressor or inotropes. - Patients need muscle relaxant. - Patients need postoperative mechanical ventilation more than 24 hours.

Design outcomes

Primary

Measure	Time frame
compare ketamine-propofol (KP) and ketamine-dexmedetomidine (KD) combinations for sedation and analgesia in patients after coronary artery bypass graft surgery	—

Secondary

Measure	Time frame
hemodynamics, total fentanyl dose, duration of mechanical ventilation and any adverse outcome	—

Countries

Egypt

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026