Evaluation of the effect of larval source management and housing improvement when added to an existing malaria control strategy

Conditions

Malaria

Mphatso D. Phiri, Robert S. McCann, Alinune N. Kabaghe, Henk van den Berg, Tumaini Malenga et al. (12 authors)

Malaria Journal2021-06-1333 citations

The effect of community-driven larval source management and house improvement on malaria transmission when added to the standard malaria control strategies in Malawi: a cluster-randomized controlled trial.

McCann RS, Kabaghe AN, Moraga P, Gowelo S, Mburu MM, Tizifa T, Chipeta MG, Nkhono W, Di Pasquale A, Maire N, Manda-Taylor L, Mzilahowa T, van den Berg H, Diggle PJ, Terlouw DJ, Takken W, van Vugt M, Phiri KS.

2021-05-2234 citations

10.1186/s12936-021-03769-0

Assessment of the effect of larval source management and house improvement on malaria transmission when added to standard malaria control strategies in southern Malawi: study protocol for a cluster-randomised controlled trial.

McCann RS, van den Berg H, Diggle PJ, van Vugt M, Terlouw DJ, Phiri KS, Di Pasquale A, Maire N, Gowelo S, Mburu MM, Kabaghe AN, Mzilahowa T, Chipeta MG, Takken W.

2017-09-2239 citations

10.1186/s12879-017-2749-2

Interventions

Standard prevention with LLINs

LSM + HI (in addition to LLINs)

Larval Source Management (in addition to LLINs)

House Improvement (in addition to LLINs)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All villages in the demarcated study site will initially be eligible for full participation in the trial. All households in trial villages will be eligible for entomological and epidemiological monitoring to assess trial outcomes. Within these households, children aged 6 to 59 months with informed consent from a guardian will be eligible for assessing parasitemia.

Exclusion criteria

Exclusion criteria: A buffer zone around each trial village, necessary for preventing contamination bias, will lead to the exclusion of some villages in the study site from the trial. This will be kept to a minimum, and done randomly by applying a spatial restriction to the village selection procedure.

Design outcomes

Primary

Measure	Time frame
Entomological inoculation rate;Prevalence of anaemia in children aged 6-59 months	—

Secondary

Measure	Time frame
Malaria vector community composition;Malaria vector human blood index;Peak malaria vector biting time;Larval mosquito density;Parasite prevalence in children aged 6-59 months;Incidence of clinical malaria in children aged 6-59 months	—

Countries

Malawi

Contacts

Public ContactWillem Takken

Professor / Wageningen University

willem.takken@wur.nl+31 317 48 46 52

Outcome results

None listed