Effect of sodium bicarbonate 8.4% on bronchial carcinoma

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201602001488346

Enrollment

Registered

2016-02-24

Start date

2016-02-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer Respiratory Bronchogenic Carcinoma

Interventions

Intra-tumoral injection of sodium bicarbonate 8.4% via fiberoptic bronchoscopy

Inhalation of nebulized sodium bicarbonate 8.4%

image guided intra-tumoral injection of sodium bicarbonate 8.4%

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1- Histologically-diagnosed primary lung cancer either central lung cancer diagnosed with bronchoscopic biopsies or peripheral lung cancer diagnosed with CT or ultrasound ¿ guided biopsies. 2- Patients who are candidates for chemotherapy either because of the cell type as small cell lung cancer or advanced stage non -small cell lung cancer or early stages of lung cancer but not candidates for surgical treatment because of poor cardiopulmonary status or refusal of surgery.

Exclusion criteria

Exclusion criteria: Patients with one or more of the following: 1. Pulmonary metastasis from extrathoracic primary tumor. 2. Patients unfit for FOB. 3. Patients who are candidates for surgical resection. 4. Patients who refuse the study

Design outcomes

Primary

Measure	Time frame
Cathepsin B level and expression ;histopathological changes;electron microscopic changes;clinical presentation;tumor volume on radiology	—

Secondary

Measure	Time frame
Matrix metalloproteinases-9 level and expression;Safety of the procedure	—

Countries

Egypt

Contacts

Public ContactDina Abouelkheir Abdalla

Lecturer of Chest Medicine- Faculty of Medicine ¿ Mansoura University

dkhair@mans.edu.eg002 01009976012

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026