trachomatous trichiasis Surgery Trachomatous trichiasis
Conditions
Interventions
Doxycycline
Placebo
Sponsors
London School of Hygiene & Tropical Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Trachomatous Trichiasis with tarsal conjunctival scarring 2. Adults (>18 years of age) 3. Agree to be randomly allocated to receive doxycycline or placebo following surgery 4. Agree to re-examination at one week, one, six and twelve months after surgery
Exclusion criteria
Exclusion criteria: 1. Age less than 18 years 2. Pregnant or breast-feeding women 3. Previous eyelid surgery 4. Medically unfit, BP systolic >170, diastolic >110 5. People with known history of hypersensitivity/allergy to Doxycycline or Tetracycline 6. Presence of contra-indication to doxycycline usage o Taking warfarin o Taking sulphonylurea based medication for diabetes o Pre-existing known liver or renal impairment o Myasthenia gravis 7. Patients with trichiasis from other eyelid pathologies, such as: o Blepharitis o Steven Johnson syndrome o Burn o Trauma o Eyelid muscle laxity due to aging o Herpes zoster o Ocular cicatricial pemphigoid
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrent trichiasis following surgery;Recurrent trichiasis following surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of recurrent trichiasis;Severity of recurrent trichiasis;Conjunctival inflammation;Change in corneal opacification;Change in visual acuity;Complication Rates;Patient perspectives on the results of surgery;Side effects | — |
Countries
Ethiopia
Contacts
Public ContactEsmael Habtamu
Trial Coordinator
Outcome results
None listed