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TENDAI STUDY: Treatment to reduce depression and improve adherence to anti-retroviral therapy in Harare, Zimbabwe

Treatment to reduce depression and improve adherence to anti-retroviral therapy in Harare, Zimbabwe

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
PACTR
Registry ID
PACTR201511001150307
Enrollment
60
Registered
2015-05-27
Start date
2014-06-02
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Interventions

LifeSteps and Problem Solving Therapy
Standard care - adherence counselling

Sponsors

King's College London
Lead Sponsor
UZ-CHS NECTAR
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Aged 18 or above 2. On ART for at least 4 months as confirmed by pharmacy records 3. Score ¿ 10 OR meet criteria for a diagnosis of depression on the 9 item Patient Health Questionnaire (PHQ-9) OR Score ¿ 9 on the Shona Symptom Questionnaire (SSQ-14) 4. Screen positive for recent non-adherence, as detected by any of the following methods: i) Self Report Adherence Questionnaire ii) Missed one HIV clinic appointment in the previous 6 months iii) Falling CD4 count (CD4 below 350 that has fallen by at least 50 in the past 6 months) iv) Detectable viral loads

Exclusion criteria

Exclusion criteria: 1. Score ¿6 on the International HIV Dementia Scale (IHDS) 2. Score of 3 or higher for women and a score of 4 or higher for men on the short AUDIT-C screen for alcohol dependance 3. On medication for tuberculosis 4.Have suicidal intent as determined by the P4 Suicidality Screener 5. Interviewer assesses person too unwell and/ agitated to take part

Design outcomes

Primary

MeasureTime frame
Depression Score;Wisepill Adherence Percentage

Secondary

MeasureTime frame
Viral Load

Countries

Zimbabwe

Contacts

Public ContactMelanie Abas

Reader in Global Mental Health (King's College London)

melanie.abas@kcl.ac.uk+442078480316

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026