Effect of S (+) ketamine on the release of proinflammatory cytokines

Effect of single versus repeated doses of intravenous S (+) ketamine on the release of proinflammatory cytokines in patients undergoing radical prostatectomy.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201510001293646

Enrollment

Registered

2015-10-04

Start date

2015-10-06

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Urological and Genital Diseases release of cytokines Anaesthesia

Interventions

Group I: received combined epidural-general anesthesia without S (+) ketamine

Group II: received combined epidural-general anesthesia and S (+) ketamine as a single preincision d

Group III: received combined epidural-general anesthesia and S (+) ketamine as preincision and repea

Eligibility

Sex/Gender

Male

Inclusion criteria

Inclusion criteria: ASA physical status I¿II, aged 45-65 years old scheduled for radical cystectomy under combined epidural general anesthesia

Exclusion criteria

Exclusion criteria: ASA physical status > ¿I, morbid obesity (body mass index > 35), pre-existing neurological or psychiatric disorders, chronic drug abuse, the use of drugs affecting immunity as chemotherapy or hormonal therapy, uncontrolled diabetics, renal, hepatic, hypertensive patients, contraindication for epidural catheter insertion, hypersensitivity for any anesthetics or drug used.

Design outcomes

Primary

Measure	Time frame
release of proinflammatory cytokines	—

Secondary

Measure	Time frame
hemodynamics, pain relief, PONV	—

Countries

Egypt

Contacts

Public ContactHassan Ali

MD degree, lecturer of anesthesia, pain and surgical ICU

hassan364@hotmail.com+201001733687

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026