Drug therapeutic efficacy testing

Conditions

Malaria

Akintunde Sowunmi, Godwin Ntadom, Kazeem Akano, Folasade O. Ibironke, Adejumoke Idowu Ayede et al. (36 authors)

Infectious Diseases of Poverty2019-08-0619 citations

Therapeutic efficacy and effects of artemisinin-based combination treatments on uncomplicated Plasmodium falciparum malaria -associated anaemia in Nigerian children during seven years of adoption as first-line treatments.

Sowunmi A, Akano K, Ntadom G, Ayede AI, Ibironke FO, Aderoyeje T, Adewoye EO, Fatunmbi B, Oguche S, Okafor HU, Watila I, Meremikwu M, Agomo P, Ogala W, Agomo C, Folarin OA, Gbotosho GO, Happi CT.

2017-02-0712 citations

10.1186/s40249-016-0217-7

Early rising asexual parasitaemia in Nigerian children following a first dose of artemisinin-based combination treatments of falciparum malaria

Akintunde Sowunmi, Kazeem Akano, Adejumoke Idowu Ayede, Elsie O. Adewoye, Godwin Ntadom et al. (9 authors)

BMC Infectious Diseases2017-01-317 citations

10.1186/s12879-016-2173-z

Therapeutic efficacy and effects of artesunate-amodiaquine and artemether-lumefantrine on malaria-associated anaemia in Nigerian children aged two years and under.

Sowunmi A, Akano K, Ayede AI, Ntadom G, Adewoye EO, Fatunmbi B, Aderoyeje T.

2016-07-065 citations

10.1186/s40249-016-0165-2

Clinical illness and outcomes in Nigerian children with late-appearing anaemia after artemisinin-based combination treatments of uncomplicated falciparum malaria.

Sowunmi A, Akano K, Ayede AI, Ntadom G, Aderoyeje T, Adewoye EO, Fatunmbi B.

2016-06-0111 citations

10.1186/s12879-016-1565-4

Interventions

artemether plus lumefantrine

artesunate plus amodiaquine

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Children age 6¿59 months. History of fever / Measured fever (temp > 37.4). Mono P. falciparum infection with parasitemia >/=1000 to </= 200,000 parasites per microlitre of blood. Written informed consent, including readiness to comply with follow up visits by the child¿s parent or other adult guardian.

Exclusion criteria

Exclusion criteria: Signs of severe malaria or other danger signs, such as: 1. Unconsciousness 2. Not able to sit or stand 3. Severe anaemia (Hb </= 5 g/dL) 4. Convulsions 5. Shock (systolic BP < 50 mmHg) 6. Inability to drink or breastfeed 7. Vomiting everything Other diseases associated with fever. Severe malnutrition. History of allergy to test drugs.

Design outcomes

Primary

Measure	Time frame
Early treatment failure;Late clinical failure;Late parasitological failure;Adequate clinical and parasotilogical response	—

Secondary

Measure	Time frame
Fever clearance time;Parasite clearance time;Gametocyte carriage	—

Countries

Nigeria

Contacts

Public ContactBayo Fatunmbi

Technical Officer (Monitoring & Evaluation)

fatunmbib@wpro.who.int+855 (0) 12468793

Outcome results

None listed