Tuberculosis
Conditions
Interventions
mHealth contact investigation
Standard contact investigation
Sponsors
NIH-NIAID
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Index TB patients: 1. Reported to the NTLP by appearing in the NTLP TB treatment register, as one of the following: a)New microbiologically confirmed pulmonary TB patient; b) AFB sputum smear-positive; c)GeneXpert-positive; d)Mtb culture-positive; e) Child under 5 with newly diagnosed TB of any form even without microbiologic confirmation 2. Residing with the political boundaries of Kampala 3. Any age (including children and emancipated minors) 4. Any gender Household contacts: 1. Sleeping under same roof as the index TB patient for >5 nights in the previous 3 months 2. Any age (including children and emancipated minors) 3. Any gender
Exclusion criteria
Exclusion criteria: Index TB patients: 1. Unable to provide informed consent (e.g. lacking capacity) 2. Unwilling to provide informed consent 3. MDR-TB patient (will be referred to the NTLP MDR-TB program for contact investigation) 4. No contacts living in the household or homeless 5. Previously enrolled in the study as a household contact 6. No access to a mobile telephone in the household 7. Not conversant in Luganda or English 8. Unwilling to participate for any reason after first consenting to screening Household contacts: 1. Unable to provide informed consent (e.g. lacking capacity) 2. Unwilling to provide informed consent 3. Currently taking treatment for active TB 4. No access to a mobile telephone 5. Not conversant in Luganda or English 6. Unwilling to participate for any reason after first consenting to screening
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Yield: Return defined as numerical count of contacts completing TB evaluation within 14 days of index patient diagnosis, divided by total number eligible household contacts equals yield of initial home visit. ;Yield of serial SMS screening: for the 4 6-monthly interval SMS screenin interventions over 2 years, defined as added TB evaulations completed within 14 days of SMS over baseline;(2)Yield for HIV diagnosis: Proportion of tested contacts diagnosed with HIV;3).Yield of home sputum collection (1)Proportion of screen-positive contacts successfully providing sputum, by risk group;3b). Yield of mHealth interventions, by risk group;3c).Time to impact of SMS;4a)Cost-effectiveness outcomes i)Primary Outcomes: Incremental Cost Effectiveness Ratio (1)mHealth CI compared to standard CI (2)mHealth CI compared to no CI (modeled using inputs from published literature) | — |
Countries
Uganda
Contacts
Public ContactIrene Ayakaka
Project Manager
Outcome results
None listed