HEMODYNAMIC CHANGES AND STRESS RESPONSE DURING BIS-GUIDED TCI ANESTHESIA WITH PROPOFOL-FENTANYL IN LAPAROSCOPIC VERSUS OPEN CHOLECYSTECTOMY

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201506001134401

Enrollment

Registered

2015-05-08

Start date

2015-01-03

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Circulatory System Surgery chronic calcular choecystitis Anaesthesia

Interventions

laparoscopic surgery group (group LS)

open surgery group (group OS)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: adult patients 25-55 years old ASA physical status I or II either sex scheduled for laparoscopic or open cholecystectomy under general anesthesia using TIVA with propofol fentanyl delivered by TCI pump

Exclusion criteria

Exclusion criteria: esophageal abnormalities obesity (BMI > 35 kg.m-2) pregnancy and lactation chronic liver disease diabetes mellitus severe renal, endocrine, rheumatic, cardiopulmonary disease malignancy patients receiving medications with known effects on the sympathetic response or the hormonal secretion e.g. ¿-Blockers

Design outcomes

Primary

Measure	Time frame
the effect of this technique on the cardiac output as measured using esophageal Doppler monitoring	—

Secondary

Measure	Time frame
HEMODYNAMIC MEASUREMENTS: Heart rate (HR) (beat.min-1) and mean arterial pressure (MAP) (mmg Hg), Flow time corrected (FTc) (msec), Peak velocity (PV) (cm.sec-1), Stroke distance (SD) (cm), Mean acceleration (cm.sec-2), Minute distance (MD) (cm), Stroke volume (SV) (ml), Systemic vascular resistance (SVR) (dynes.sec-1.cm¿5) ;LABORATORY MEASUREMENTS:stress hormones will be estimated in the samples: epinephrine, norepinephrine, ACTH, cortisol as well as blood glucose level	—

Measure

Time frame

HEMODYNAMIC MEASUREMENTS: Heart rate (HR) (beat.min-1) and mean arterial pressure (MAP) (mmg Hg), Flow time corrected (FTc) (msec), Peak velocity (PV) (cm.sec-1), Stroke distance (SD) (cm), Mean acceleration (cm.sec-2), Minute distance (MD) (cm), Stroke volume (SV) (ml), Systemic vascular resistance (SVR) (dynes.sec-1.cm¿5) ;LABORATORY MEASUREMENTS:stress hormones will be estimated in the samples: epinephrine, norepinephrine, ACTH, cortisol as well as blood glucose level

—

Countries

Egypt

Contacts

Public ContactMohamed Zeidan

Associate Professor

zeidanoma@hotmail.com+201111113115

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Aug 9, 2026