Effect of adding dexmeditomidine to epidural bupivacaine

A dose reduction study of local anesthetic with addition of dexmedetomidine on postoperative epidural analgesia for patients undergoing total knee arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201503001068335

Enrollment

Registered

2015-03-11

Start date

2012-01-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgery knee arthroplasty Anaesthesia

Interventions

bupivacaine 0.125%

dexmeditomidine 0.2 microgram/kg/h+ bupivacaine0.125%

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 75 patients, 50¿70 years old, ASA physical status I - III undergoing elective total knee arthroplasty were randomly divided into three equal groups

Exclusion criteria

Exclusion criteria: morbid obese, age older than 70 years, known allergy to bupivacaine or dexmedetomidine, renal or hepatic insufficiency, cardiac conduction disturbances, neurological or psychiatric diseases and coagulation disorders

Design outcomes

Primary

Measure	Time frame
volume of local anesthetic	—

Countries

Egypt

Contacts

Public Contactayman ebied

assistant professor, menofiya faculty of medicine

ayman_ebeid@hotmail.com00201004262759

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026