Comparison between the roles of low dose aspirin and folic acid in preventing preeclampsia among high risk women screened by uterine artery Doppler at

Comparison between the roles of low dose aspirin and folic acid in preventing preeclampsia among high risk women screened by uterine artery Doppler at 22-24 weeks of gestation: A randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201503001054393

Enrollment

210

Registered

2015-03-04

Start date

2013-05-07

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pregnancy and Childbirth Preeclampsia

Interventions

Aspirin

Folic acid

No treatment

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: -Uterine artery Doppler resistance index exceeds 0.68 with or without an early diastolic notch at 22-24 weeks of geatation. -High risk patients for developing preeclampsia defined by having any of the following risk factors: chronic hypertension, pregestational diabetes mellitus, body mass index (BMI) > 30kg/m² or past history of preeclampsia

Exclusion criteria

Exclusion criteria: Multifetal pregnancy. Antiphospholipid syndrome. Ruptured membranes. Major congenital anomalies. Patients already receiving prophylactic therapy. Patients with known allergy to aspirin or folic acid

Design outcomes

Primary

Measure	Time frame
Preeclampsia development	—

Secondary

Measure	Time frame
Early onset eclampsia;Severe preeclampsia	—

Countries

Egypt

Contacts

Public ContactAbdelGany Hassan

Lecturer of Gynecology and Obstetrics, Cairo university, Egypt

abdelgany2@gmail.com+201017801604

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026