Aetiology of treatment failure in HIV positive children and adolescents on boosted protease inhibitor based regimens.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201502001028169

Enrollment

130

Registered

2015-02-04

Start date

2014-07-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS

Interventions

Directly administered antiretroviral therapy (DAART)

Self administered therapy (SAT)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Parents/guardian willing to consent 2. Child willing to provide assent 3. Documented HIV positive antibody or antigen test 4. Child knows their HIV status 5. Aged between 6 and 16 years (that is, from the day of their sixth birthday up to the eve of their seventeenth birthday) 6. Registered at Harare hospital paediatric opportunistic infections clinic 7. On second line treatment (ATV/r based) 8. Have taken the above named second line treatment for at least 6 complete, consecutive months 9. Has virological and immunological treatment failure as defined by WHO 2012 criteria

Exclusion criteria

Exclusion criteria: 1. Patients registered at other health centres who have been referred for specialist care at Harare hospital paediatric opportunistic infections clinic 2. On ATV/r as first line treatment 3. Patients who do not want to be followed up at home.

Design outcomes

Primary

Measure	Time frame
Virological failure	—

Secondary

Measure	Time frame
Atazanavir concentration in hair	—

Countries

Zimbabwe

Contacts

Public ContactTariro Chawana

DPhil student

tdchawana@gmail.com+263 773 276 306

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026