A RANDOMIZED CONTROL TRIAL COMPARING TRAIN OF FOUR RATIO ¿0.9 TO CLINICAL ASSESSMENT OF RETURN OF NEUROMUSCULAR FUNCTION BEFORE ENDOTRACHEAL EXTUBATI

A RANDOMIZED CONTROL TRIAL COMPARING TRAIN OF FOUR RATIO ¿0.9 TO CLINICAL ASSESSMENT OF RETURN OF NEUROMUSCULAR FUNCTION BEFORE ENDOTRACHEAL EXTUBATION ON CRITICAL RESPIRATORY EVENTS IN ADULT PATIENTS UNDERGOING ELECTIVE SURGERY AT THE AGA KHAN UNIVERSITY HOSPITAL NAIROBI.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201501001021110

Enrollment

168

Registered

2015-01-30

Start date

2014-04-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Respiratory Critical respiratory events in post anaesthesia care unit

Interventions

Clinical assessment group

TOF ratio group

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Adults aged 18-65 years old, American society of anaesthesiology (ASA) physical status I and II undergoing elective surgery under general anaesthesia using cisatracurium.

Exclusion criteria

Exclusion criteria: 1. ASA status III and above 2. Pregnant women 3. Patients with neuromuscular diseases 4. Patients on medications that interfere with neuromuscular junction function. For example, magnesium sulphate and aminoglycosides 5. Patients with renal, hepatic or respiratory diseases 6. Patient refusal 7. Patients with BMI >30 8. Patients allergic to cisatracurium 9. Patients undergoing brain surgery

Design outcomes

Primary

Measure	Time frame
Whether using train of four ( TOF) ratio ¿0.9 before extubation reduces incidence of critical respiratory events (hypoxemia and upper airway obstruction) in PACU	—

Secondary

Measure	Time frame
Incidence of hypoxemia and upper airway in PACU	—

Countries

Kenya

Contacts

Public ContactJoan Irungu

Programme Administrator, Department of Anaesthesia Aga Khan University Nairobi

joan.irungu@aku.edu+254 732 277457

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026