Comparative study between intravenous versus epidural lignocaine in ischemia reperfusion injury during total knee arthroplasty

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201411000929541

Enrollment

Registered

2014-11-06

Start date

2013-10-15

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Injury, Occupational Diseases, Poisoning Surgery Total knee replacement

Interventions

Intravenous lignocaine

Epidural lignocaine

Controls

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: elective unilateral total knee arthroplasty due to osteoarithitis

Exclusion criteria

Exclusion criteria: -patients using alpha or beta blockers -patients with allergy to other amide local anesthetics - impaired liver functions - chronic use of corticosteroids or non steroidal anti-inflammatory diseases - patients with chronic inflammatory diseases - heart block - antibiotic treatment or inter-current infections -pagets disease -revision arthroplasty 10- cancer 11- vascular disorders

Design outcomes

Primary

Measure	Time frame
Total leukocyte count;Intracellular hydrogen peroxide;Soluble intercellular adhesion molecule;Von willbrand factor	—

Secondary

Measure	Time frame
Assessment of pain	—

Countries

Egypt

Contacts

Public ContactElsayedamr Basma

Patient Information Manager

elsayedamr@yahoo.com002-01223106023

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Feb 4, 2026