IMSI versus ICSI in patients with severe male factor infertility and repeated ICSI failure

Comparative study between intracytoplasmic morphologically selected sperm injection (IMSI) versus intracytoplasmic sperm injection(ICSI) in patients with severe male factor infertility and repeated ICSI failure

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201411000928146

Enrollment

140

Registered

2014-11-06

Start date

2014-10-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fertility-male Fertility-female Infertility with repeated ICSI failure

Interventions

ICSI

IMSI

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Primary or secondary infertility Having good ovarian reserve(AMH>1.5,AFC >5 and basal FSH< 10mIu/L ) All underwent the long luteal gonadotrophin agonist proto- Col for ovarian stimulation. All with at least one previous failed ICSI Male partner with sever oligospermia sperm conc < 5(106 Per ml) and sever teratospermia normal form <4%.

Exclusion criteria

Exclusion criteria: Endocrine disorders Associated other medical conditions (hypertention, diabetes) Abnormal uterine factor diagnosed by vaginal sonogrphy, Hysteroscopy, Hysterosalpingography or previous uterine surgery. Stage IV endometriosis or previous ovarian surgery. Male partners with TESE (testicular epididimal sperm extraction)

Design outcomes

Primary

Measure	Time frame
Number of embryos;Fertilization rate;Embryo grading.;Implantation rate .	—

Secondary

Measure	Time frame
Pregnancy rate	—

Countries

Egypt

Contacts

Public ContactElsayedamr Basma

Patient Information Manager

elsayedamr@yahoo.com002-01223106023

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026