Circulatory System Surgery Cirrhotic patients after liver resection
Conditions
Interventions
Sugammadex / Liver cirrhosis
Neostigmine / Liver cirrhosis
Sugammadex/ Normal liver
Neostigmine / Normal liver
Sponsors
National liver institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: American Society of Anesthesiologists physical status class I-III (Class I in patients with preoperative normal liver functions). Thirty patients categorized as Child classification ¿A¿ with a Model for End-Stage Liver Disease (MELD) score <10. Additional 30 patients with normal preoperative liver functions will serve as controls
Exclusion criteria
Exclusion criteria: Co-existing neuromuscular disease, body mass index more than 35 kg/m-2, renal impairment, medications known to affect neuromuscular transmission e.g. aminoglycoside antibiotics or magnesium sulphate, bleeding tendency, and intraoperative events e.g. (massive bleeding and hypothermia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The time from the start of sugammadex or neostigmine administration to recovery of the TOF ratio to 0.9 | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of anaesthesia and surgery.;Total dose of rocuronium. | — |
Countries
Egypt
Contacts
Public ContactElsayedamr Basma
Patient Information Manager
Outcome results
None listed