Pregnancy and Childbirth preterm labour
Conditions
Interventions
oral nicorandil
Sponsors
Menoufia faculty of medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: All women who presented to the labor ward between 24 and 34 weeks of pregnancy (determined by the date of the last menstrual period when known or by early ultrasound) will be assessed for enrollment into the study.
Exclusion criteria
Exclusion criteria: -Cervix dilatation greater than 5 cm. -Polyhydramnios [amniotic fluid index (AFI) greater than 20 cm] and oligohydramnios (AFI less than 10 cm). -Fetal macrosomia (estimated fetal weight of 4 kg or more). - Suspected intrauterine infection (a temperature greater than 38°C). -Growth restriction. -Major antepartum hemorrhage. -Major maternal medical disorders. - Multiple pregnancy. -Hypertension in pregnancy and blood pressure less than 90/50 mm Hg. -Signs of fetal distress. -Lethal fetal anomaly. -Contraindication for the use of nifedipine and/or nicorandil.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prolongation of pregnancy for a period of 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse effects of both drugs;Prolongation of pregnancy;Neonatal outcome | — |
Countries
Egypt
Contacts
Public ContactRagab Dawood
lecturer at department of obstetrics and gynecology, menoufia faculty of medicine
Outcome results
None listed