The effectiveness of intermittent screening and treatment (IST) of malaria in pregnancy in South East Nigeria

Intermittent preventive treatment versus intermittent screening and treatment of malaria in pregnancy

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201308000543272

Enrollment

460

Registered

2013-04-29

Start date

2013-07-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malaria Pregnancy and Childbirth

Interventions

Intermittent preventive treatment of malaria in pregnancy (IPTp) with sulphadoxine-pyrimethamine

Intermittent screening and treatment of malaria in pregnancy (IST) with artemether-lumefantrine

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Pregnancy (16-24 weeks gestation) confirmed at first booking Willing to have supervised delivery Permanent residence within the study area

Exclusion criteria

Exclusion criteria: Haemoglobin < 6.0 g/dl or haematocrit of <18% Presence of malaria requiring parenteral medication or parasite density ¿ 100,000/mm3 of blood. Past obstetric and medical history that will adversely affect the evaluation of outcomes. A prior dose of SP-IPTp Sensitivity to SP, lumefantrine or an artemisinin An illness requiring hospital admission. Known G6PD deficiency to exclude women at risk of haemolytic anaemia. Women who are known to be HIV infected before enrollment will not be recruited because, according to World Health Organization (WHO) and national recommendations, they should receive 3 (rather than 2) IPTp doses. Failure to meet any of the inclusion criteria stated above.

Design outcomes

Primary

Measure	Time frame
Prevalence of severe maternal anaemia (Hb < 8g/dl) of gestation	—

Secondary

Measure	Time frame
Prevalence of low birth weight (< 2500g) ;Prevalence of maternal anaemia (Hb < 11g/dl);Prevalence of placental malaria;Prevalence and density of microscopical and sub-microscopical gametocytamia;Prevalence and density of maternal parasitaemia;Congenital anomalies in live births;Prevalence of neonatal mortality;Prevalence of maternal mortality;Proportions of spontaneous abortions, intrauterine deaths, stillbirths, and pre-term deliveries	—

Measure

Time frame

Prevalence of low birth weight (< 2500g) ;Prevalence of maternal anaemia (Hb < 11g/dl);Prevalence of placental malaria;Prevalence and density of microscopical and sub-microscopical gametocytamia;Prevalence and density of maternal parasitaemia;Congenital anomalies in live births;Prevalence of neonatal mortality;Prevalence of maternal mortality;Proportions of spontaneous abortions, intrauterine deaths, stillbirths, and pre-term deliveries

—

Countries

Nigeria

Contacts

Public ContactEkpereonne Esu

Lecturer

ekpereonneesu@gmail.com+2347065810085

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026