To determine if 0.2% topical Nifedipine has better healing rates than 0.2% topical Glyceryl Trinitrate in the treatment of Chronic Anal Fissures

A RANDOMISED CLINICAL TRIAL COMPARING TOPICAL 0.2% NIFEDIPINE VS. 0.2% GLYCERYL TRINITRATE FOR THE TREATMENT OF CHRONIC ANAL FISSURES

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201304000524290

Enrollment

Registered

2013-03-18

Start date

2013-05-01

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Digestive System Chronic Anal Fissure

Interventions

Group A

Group B

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age : 18 years or older 2. History of anal pain on defecation for at least 6 weeks ± 3. Presence of any 1 of the following: -Sentinel pile -Hypertrophied apical papilla or -Visible fibres of IAS

Exclusion criteria

Exclusion criteria: 1.Fissures not consistent with above diagnostic criteria 2.Previous surgery for anal fissure 3.Fissures secondary to other diseases e.g. Crohn¿s disease, ulcerative colitis, malignancies, tuberculosis etc. 4.Associated complications warranting surgery (abscess, fistula etc) 5.Coexistent medical conditions using calcium channel blocker and oral, sublingual or transdermal nitrates

Design outcomes

Primary

Measure	Time frame
The overall healing rate of Nifedipine vs GTN-treated patients with chronic anal fissure	—

Secondary

Measure	Time frame
What proportion of participants have epithelialization or formation of a scar by 2, 4, 6 and 8 weeks;The resolution of pain	—

Countries

Kenya

Contacts

Public ContactMark Siboe

Surgeon

marxiboy@gmail.com+254722538322

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026