ZENITH

Conditions

HIV/AIDS

Chido Dziva Chikwari, Victoria Simms, Joanna Busza, Ethel Dauya, Tsitsi Bandason et al. (9 authors)

Implementation Science2018-05-2323 citations

The effect of community-based support for caregivers on the risk of virological failure in children and adolescents with HIV in Harare, Zimbabwe (ZENITH): an open-label, randomised controlled trial.

Ferrand RA, Simms V, Dauya E, Bandason T, Mchugh G, Mujuru H, Chonzi P, Busza J, Kranzer K, Munyati S, Weiss HA, Hayes RJ.

2017-11-0157 citations

10.1016/s2352-4642(17)30051-2

Interventions

Provision of support to households of HIV+ve children delivered by lay workers

Clinic Based care

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Age 6-15 years Testing HIV-positive at the study primary care clinics Based in the study clusters (each study suburb to have demarcated clusters) Guardian consent and participant assent

Exclusion criteria

Exclusion criteria: No Guardian consent and/or participant assent Age not 6-15 years Child not residing within study clusters Already in HIV care

Design outcomes

Primary

Measure	Time frame
2 or more scheduled clinic appointments missed in 2 years;2 or more scheduled clinic appointments missed in 18 months years;2 or more scheduled clinic appointments missed in 18 months	—

Secondary

Measure	Time frame
All-cause mortality;Numbers of and time to first hospital admission (as defined by hospital stay of longer than 24 hours);Numbers of additional attendances (over and above routine follow-up) to PHC;Proportion of children who have an average adherence rate <80% 12 months starting ART;Proportion of children who change to 2nd line ART as defined by National Guidelines (due to reasons not related to toxicity, side-effects or starting TB treatment);Proportion of children who change to 2nd line ART as defined by National Guidelines (due to reasons not related to toxicity, side-effects or starting TB treatment)	—

Measure

Time frame

All-cause mortality;Numbers of and time to first hospital admission (as defined by hospital stay of longer than 24 hours);Numbers of additional attendances (over and above routine follow-up) to PHC;Proportion of children who have an average adherence rate <80% 12 months starting ART;Proportion of children who change to 2nd line ART as defined by National Guidelines (due to reasons not related to toxicity, side-effects or starting TB treatment);Proportion of children who change to 2nd line ART as defined by National Guidelines (due to reasons not related to toxicity, side-effects or starting TB treatment)

—

Countries

Zimbabwe

Contacts

Public ContactRashida Ferrand

rashida.ferrand@lshtm.ac.uk+263772165755

Outcome results

None listed