Malaria
Conditions
Interventions
Sponsors
Kenya Medical Research Institute
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 6-59 months 2. Axillary temperature equal to or above 37.5º C or history of fever in the past 48 hours 3. Body weight above 5.0 kg 4. Slide-confirmed infection with P. falciparum 5. Parasitaemia 2,000-200,000 asexual forms per microlitre 6. Parent/guardian provides informed consent
Exclusion criteria
Exclusion criteria: 1. Presence of general danger signs or other signs of severe malaria and complicated falciparum malaria according to current WHO definitions. 2. Mixed or mono-infection with another Plasmodium species. 3. Presence of severe malnutrition, defined as weight-for-age below 3 standard deviations below the mean (NCHS/WHO normalized reference values). 4. Known hypersensitivity to any of the drugs being tested. 5. Presence of febrile conditions caused by diseases other than malaria. 6. Presence of other serious or chronic medical conditions (heart failure, sickle cell disease). 7. Plan to travel or leave the area within the next 3 months 8. Inability to swallow oral medication 9. Residence beyond 10km of the catchment area of the study hospital.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cure rate | — |
Secondary
| Measure | Time frame |
|---|---|
| Fever resolution rate;parasite clearance rate;gametocyte carriage;haemoglobin | — |
Countries
Kenya
Contacts
Public ContactJohn Vulule
Centre Director, KEMRI Kisumu
Outcome results
None listed