The pharmacokinetics of lopinavir/ritonavir, nevirapine and efavirenz when given with isoniazid in South African HIV-infected individuals

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

PACTR

Registry ID

PACTR201206000391313

Enrollment

Registered

2012-06-14

Start date

2012-06-21

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HIV/AIDS Tuberculosis

Interventions

Isoniazid

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Stable on ART: efavirenz, nevirapine or lopinavir/ritonavir

Exclusion criteria

Exclusion criteria: Hepatitis Pregnant Using CYP450 inducers/inhibitors Excessive alchol use Intolerant to isoniazid

Design outcomes

Primary

Measure	Time frame
Pharmacokinetics of lopinavir	—

Secondary

Measure	Time frame
Safety	—

Countries

South Africa

Contacts

Public ContactEric Decloedt

Division of Clinical Pharmacology

eric.decloedt@uct.ac.za021 406 6353

Outcome results

None listed

Source: PACTR (via WHO ICTRP) · Data processed: Sep 19, 2026